Restarting Anticoagulation Therapy After Warfarin-Associated Intracerebral Hemorrhage

• DOI: 10.1001/archneur.65.10.1313
• Publication Date: 2008-10-13T20:18:24Z
• Authors: Daniel O. Claassen; Noojan Kazemi; Alexander Y. Zubkov; Eelco F. M. Wijdicks; Alejandro A. Rabi...
• Keywords: Discontinuation; Stroke

Reinitiating warfarin sodium therapy in a patient with recent warfarin-related intracerebral hemorrhage (WAICH) is difficult clinical decision. Therefore, it important to assess the outcome of resumption or discontinuation after WAICH.To compare patients who survived an episode WAICH and restarted group did not resume therapy. Design, Setting, Patients We conducted follow-up study from November 1, 2001, through December 31, 2005, cohort single center. Long-term was assessed at last via questionnaire.Recurrent thromboembolic events.Fifty-two were discharged hospital diagnosis WAICH. Four lost follow-up. Mean among all 43 (range, 1-108) months. Of 23 therapy, 1 had recurrent nontraumatic WAICH, 2 traumatic hemorrhages, major extracranial hemorrhages. 25 restart 3 stroke, pulmonary embolus, distal arterial embolus.Restarting associated low risk recurrence, but are subjected known, substantial risks use. Withholding thromboembolization.