Comparing and Combining Naltrexone and Acamprosate in Relapse Prevention of Alcoholism

• DOI: 10.1001/archpsyc.60.1.92
• Publication Date: 2010-03-02T01:49:02Z
• Authors: Falk Kiefer; Holger Jahn; Timo Tarnaske; Hauke Helwig; Peer Briken; Rüdiger Holzbach; Philipp Kämpf; Robert Stracke; Michael Baehr; Dieter Naber; Klaus Wiedemann
• Keywords: Male; Taurine; Acamprosate; Middle Aged; Naltrexone; 3. Good health; Placebos; Alcoholism; Drug Combinations; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Double-Blind Method; Secondary Prevention; Humans; Drug Therapy, Combination; Female

Naltrexone and acamprosate have been shown to be effective in relapse prevention of alcoholism via different pharmacologic mechanisms. Since it remains uncertain whether both substances are equally efficient and whether a combination of both drugs potentiates the efficacy, we conducted the first published controlled study comparing and combining both compounds.After detoxification, 160 patients with alcoholism participated in a randomized, double-blind, placebo-controlled protocol. Patients received naltrexone, acamprosate, naltrexone plus acamprosate, or placebo for 12 weeks. Patients were assessed weekly by interview, self-report, questionnaires, and laboratory screening. Time to first drink, time to relapse, and the cumulative abstinence time were the primary outcome measures.Naltrexone, acamprosate, and the combined medication were significantly more effective than placebo. Comparing the course of nonrelapse rates between naltrexone and acamprosate, the naltrexone group showed a tendency for a better outcome regarding time to first drink and time to relapse. The combined medication was most effective with significantly lower relapse rates than placebo and acamprosate but not naltrexone.The results of this study support the efficacy of pharmacotherapeutic strategies in the relapse prevention of alcoholism. Naltrexone and acamprosate, especially in combination, considerably enhance the potential of relapse prevention.