Effects of Co-occurring Cannabis Use Disorders on the Course of Bipolar Disorder After a First Hospitalization for Mania

• DOI: 10.1001/archpsyc.64.1.57
• Publication Date: 2007-01-01T16:53:51Z
• Authors: Stephen M. Strako...; Melissa P. DelBello; David E. Fleck; Caleb M. Adler; Robert M. Anthenelli; Paul E. Keck; Lesley M. Arnold; Jennifer Amicone
• Keywords: Alcohol use disorder; Bipolar I disorder; Cannabis Dependence

<h3>Context</h3> Cannabis use disorders commonly co-occur in bipolar disorder; however, the effects of cannabis abuse on outcome have been minimally studied. <h3>Objective</h3> To identify how sequence onsets a disorder and is associated with subsequent course each condition. <h3>Design</h3> Inception cohort. <h3>Setting</h3> Academic medical center. <h3>Patients</h3> Patients (N = 144) were studied who met criteria for I (manic or mixed), 12 to 45 years old, had no previous hospitalizations minimal treatment. followed up 5 included 33 whom onset preceded (cannabis first), 36 (bipolar 75 only. <h3>Main Outcome Measures</h3> Symptomatic recovery recurrence both conditions percentage follow-up time affective symptoms. <h3>Results</h3> The first group exhibited better than other groups, although when adjusted potential mediator variables these results did not persist. was more episodes rapid cycling. Most remitted immediately after hospitalization, by rates recurrence. <h3>Conclusions</h3> less pronounced observed co-occurring alcohol disorders. Aggressive drug treatment psychiatric hospitalization might decrease new cases disorder.