Metabolomic Analysis of Coronary Heart Disease in an African American Cohort From the Jackson Heart Study

• DOI: 10.1001/jamacardio.2021.4925
• Publication Date: 2021-12-01T18:04:43Z
• Authors: Daniel E. Cruz; Usman A. Tahir; Jie Hu; Debby Ngo; Zsu-Zsu Chen; Jeremy M. Robbins; Daniel Katz; Raji Balasubramanian; Bennet Peterson; Shuliang Deng; Mark D. Benson; Xu Shi; Lucas Dailey; Yan Gao; Adolfo Correa; Thomas J. Wang; Clary B. Clish; Kathryn M. Rexrode; James G. Wilson; Robert E. Gerszten
• Keywords: Subclinical infection

<h3>Importance</h3> African American individuals have disproportionate rates of coronary heart disease (CHD) but lower levels artery calcium (CAC), a marker subclinical CHD, than non-Hispanic White individuals. may distinct metabolite profiles associated with incident CHD risk compared individuals, and examination these differences could highlight important processes that differ between them. <h3>Objectives</h3> To identify novel biomarkers CAC among to replicate findings in multiethnic cohort. <h3>Design, Setting, Participants</h3> This analysis targeted plasma metabolomic profiling 2346 participants the Jackson Heart Study (JHS), prospective population-based cohort study included 5306 who were examined at baseline (2000-2004) 2 follow-up visits. Replication CHD-associated metabolites was sought 1588 from Women’s Health Initiative (WHI), 161 808 postmenopausal women (1991-1995) ongoing Regression analyses performed for each examine associations scores. Data collected WHI 1994 2009 JHS 2000 2015. All data analyzed November 2020 August 2021. <h3>Exposures</h3> Plasma metabolites. <h3>Main Outcomes Measures</h3> Incident defined as definite or probable myocardial infarction fatal both cohorts. In cohort, silent examinations (as determined by electrocardiography) revascularization analysis. Coronary measured using 16-channel computed tomographic system reported an Agatston score. <h3>Results</h3> Among mean (SD) age 56 (13) years, 1468 (62.6%) female. 67 (7) years; 217 (13.7%) self-identified American, 1219 (76.8%) White, 152 (9.6%) other races ethnicities. fully adjusted model including 1876 46 303 (false discovery rate q &lt;0.100). 32 available 13 CHD–associated replicated A total 1439 scores received profiling. Nine Minimal overlap found results analyses, only 3 shared analyses. <h3>Conclusions Relevance</h3> identified population 9 included<i>N</i>-acylamides, leucine, lipid species. These help elucidate common metabolic be different race.