Mortality in Patients With Nonfunctional Adrenal Tumors

• DOI: 10.1001/jamainternmed.2023.2442
• Publication Date: 2023-06-26T15:34:47Z
• Authors: Jekaterina Patrova; Buster Mannheimer; Jonatan D. Lindh; Henrik Falhammar
• Keywords: Male; Adenoma; Cardiovascular Diseases; Case-Control Studies; Adrenal Gland Neoplasms; Humans; Female; 3. Good health; Original Investigation; Aged; Retrospective Studies

It is unclear if nonfunctional adrenal adenomas (NFAAs) are associated with increased mortality.To analyze mortality and causes of death in patients NFAA.A national retrospective register-based case-control study was conducted included 17 726 a diagnosis adenoma Sweden from 2005 to 2019 who were identified followed up until or 2020 as well 124 366 controls without adenoma. Individuals diagnoses indicating hormonal excess cancer excluded. Follow-up started after 3 months cancer-free survival following the date NFAA diagnosis. Sensitivity analyses performed subgroups individuals for whom it assumed that would also have undergone computed tomography: those acute appendicitis (for there no concern cancer) combination gallbladder, biliary tract, pancreas disorders 6-month 12-month The data analyzed 2022.Diagnosis NFAA.The primary outcome all-cause among adjustment comorbidities socioeconomic factors. Secondary outcomes due cardiovascular diseases cancer.Among cases, 10 777 (60.8%) women, median (IQR) age 65 (57-73) years; controls, 69 514 (55.9%) 66 (58-73) years. Among overall during follow-up period (median, 6.2 years [IQR, 3.3-9.6 years]) higher compared (hazard ratio [HR] 1.43; 95 CI, 1.38-1.48; adjusted HR [aHR], 1.21; 95% 1.16-1.26). relative association similar women men (aHR, 1.22 [95% 1.15-1.28] vs 1.19 1.11-1.26]; P < .001 both groups). In contrast, larger increase younger than 1.44; 1.31-1.58) older 1.15; 1.10-1.20; interaction). Mortality 1.13-1.29), 1.54; 1.42-1.67). between remained significant magnitude all sensitivity analyses.The results this suggest an disease cancer. more pronounced individuals.