Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

• DOI: 10.1001/jamanetworkopen.2020.1007
• Publication Date: 2020-03-16T15:30:57Z
• Authors: Nikos Stratakis; David V. Conti; Eva Borras; Eduardo Sabido; Theano Roumeliotaki; Eleni Papadopoulou; Lydiane Agier; Xavier Basagana; Mariona Bustamante; Maribel Casas; Shohreh F. Farzan; Serena Fossati; Juan R. Gonzalez; Regina Grazulevic...; Barbara Heude; Lea Maitre; Rosemary R. C. Mc...; Ioannis Theologidis; Jose Urquiza; Marina Vafeiadi; Jane West; John Wright; Rob McConnell; Anne-Lise Brantsa...; Helle-Margrete Me...; Martine Vrijheid; Leda Chatzi
• Keywords: Adult; Infants -- Malalties; [SDV]Life Sciences [q-bio]; Embaràs; CHILDHOOD; CONSUMERS; 610; BLOOD-PRESSURE; 01 natural sciences; DISEASE; Pregnancy; Risk Factors; Animals; Humans; Mercuri -- Toxicologia; Prospective Studies; Child; Original Investigation; 0105 earth and related environmental sciences; RISK; Inflammation; 2. Zero hunger; INSULIN-RESISTANCE; ROLES; Incidence; Fishes; Mercury; PRENATAL METHYLMERCURY EXPOSURE; United States; 3. Good health; Maternal Exposure; Prenatal Exposure Delayed Effects; Mercury Poisoning; Female; Peix; Biomarkers

<h3>Importance</h3> The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health offspring to date is unknown. <h3>Objective</h3> To assess associations exposure with syndrome in children alterations biomarkers inflammation children. <h3>Design, Setting, Participants</h3> This population-based prospective birth cohort study used data studies performed 5 European countries (France, Greece, Norway, Spain, UK) between April 1, 2003, February 26, 2016, as part Human Early Life Exposome (HELIX) project. Mothers their singleton were followed up until aged 6 12 years. Data analyzed March 1 August 2, 2019. <h3>Exposures</h3> Maternal (measured times per week) was assessed using validated food frequency questionnaires, maternal concentration micrograms liter) whole blood cord samples. <h3>Main Outcomes Measures</h3> An aggregate score calculated the<i>z</i>scores waist circumference, systolic diastolic pressures, levels triglyceride, high-density lipoprotein cholesterol, insulin. A higher (score range, −4.9 7.5) indicated a poorer profile. Three protein panels measure several cytokines adipokines plasma <h3>Results</h3> included 805 mothers Among mothers, mean (SD) age at inclusion or delivery infant 31.3 (4.6) total 400 women (49.7%) had high educational level, 432 (53.7%) multiparous. children, 8.4 (1.5) years (age 6-12 years). 453 (56.3%) boys, 734 (91.2%) white race/ethnicity. Fish consistent recommendations (1 3 associated 1-U decrease (β = −0.96; 95% CI, −1.49 −0.42) compared low consumption (&lt;1 time after adjusting other covariates. No further observed more than week. independently an increase 2-fold 0.18; 0.01-0.34). Compared intake, moderate reduced proinflammatory integrated analysis identified cluster increased susceptibility disease, which characterized by pregnancy, levels, decreased adiponectin leptin, tumor necrosis factor α, interleukin 1β <h3>Conclusions Relevance</h3> Results this suggest that current improvements while unfavorable profile