Association of Age With SARS-CoV-2 Antibody Response

• DOI: 10.1001/jamanetworkopen.2021.4302
• Publication Date: 2021-03-22T15:31:11Z
• Authors: He S. Yang; Victoria Costa; Sabrina E. Racine...; Karen P. Acker; Jim Yee; Zhengming Chen; Mohsen Karbaschi; Robert Zuk; Sophie Rand; Ashley Sukhu; P. J. Klasse; Melissa M. Cushing; Amy Chadburn; Zhen Zhao
• Keywords: Avidity

<h3>Importance</h3> Accumulating evidence suggests that children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to manifest mild symptoms and at a lower risk of developing disease compared adults. It remains unknown how the immune response in differs from adolescents <h3>Objective</h3> To investigate association age quantity quality SARS-CoV-2 antibody responses. <h3>Design, Setting, Participants</h3> This cross-sectional study used 31 426 test results pediatric adult patients. Data were collected New York City hospital April 9 August 31, 2020. The semiquantitative immunoglobin (Ig) G levels between 85 3648 Further analysis profiles was performed on sera 126 patients aged 1 24 years. <h3>Main Outcomes Measures</h3> positivity rates IgG evaluated wide range groups (1-102 years). level, total (TAb) surrogate neutralizing (SNAb) activity, binding avidity (aged 1-10 years), 11-18 young adults 19-24 <h3>Results</h3> Among (19 797 [63.0%] female patients), 1194 (mean [SD] age, 11.0 [5.3] years) 30 232 49.2 [17.1] seroprevalence (197 [16.5%; 95% CI, 14.4%-18.7%]) (5630 [18.6%; 18.2%-19.1%]) patient populations similar. level showed negative correlation population (<i>r</i> = −0.45,<i>P</i> &lt; .001) moderate but positive 0.24,<i>P</i> .001). Patients 19 years exhibited lowest (eg, 25-30 vs years: 99 [44-180] relative fluorescence units [RFU] 443 [188-851] RFU). In subset cohort years, IgG, TAb, SNAb negatively correlated IgG:<i>r</i> −0.51; P Children higher median (IQR) levels, TAb activity levels: 473 [233-656] RFU 191 [82-349] RFU;<i>P</i> [38-150] Adolescents also than 961 [290-2074] 370 [125-697];<i>P</i> .006). addition, had adults, difference not significant. <h3>Conclusions Relevance</h3> this suggest viral specific distinct different groups. Age-targeted strategies for screening management as well vaccine development may be warranted.