Use of the Cancer and Aging Research Group Predictive Model for Chemotherapy-Related Toxic Effects in a Multiethnic, Older Adult Asian Population

• DOI: 10.1001/jamanetworkopen.2022.37196
• Publication Date: 2022-10-18T15:29:59Z
• Authors: Angela Pang; Low Jiali; Alex Ng; Joseph Cheng; Meng Wang; Yean Shin Ng; Yao Yao; Meiling Chun; Francis Ho; Jeremy Tey
• Keywords: Population Ageing

Importance The Cancer and Aging Research Group (CARG) prediction model for chemotherapy-related toxic effects has been developed but not yet validated in older Asian adults. In view of differences drug metabolism effect reporting the population, ability this tool to guide cancer treatment decision-making process adults needs be assessed. Objective To examine validity CARG predictive a multiethnic cohort Design, Setting, Participants prognostic study, patients various ethnicities 70 years or with solid tumor diagnosis receiving chemotherapy at National University Institute, Singapore, were accrued from June 1, 2017, January 2019. Their risks calculated using tool. A geriatric assessment was performed, treating oncologist (blinded scores) asked give an estimated likelihood (low, medium, high). Chemotherapy-related recorded during each clinic visit. Validation performed by calculating area under receiver operating characteristic curve. Multivariate analyses identify variables other domains predicting severe effects. Main Outcomes Measures Grade 3 5 hospitalization. Results study included 200 (median age, 74 [range, 70-89 years]; 110 [55.0%] male; 177 [88.5%] Chinese, 17 [8.5%] Malay, 4 [2.0%] Indian, 2 [1.0%] [according Singapore’s national system race classification]). total 137 (68.5%) experienced grade effects, 131 (65.5%) required curve chemotoxicity 0.74 (95% CI, 0.67-0.82), retaining good discrimination population. Conclusions Relevance This conducted supports which are risk