Association of Time to Surgery After COVID-19 Infection With Risk of Postoperative Cardiovascular Morbidity

• DOI: 10.1001/jamanetworkopen.2022.46922
• Publication Date: 2022-12-14T16:01:10Z
• Authors: John M. Bryant; Christina S. Boncyk; Kimberly F. Rengel; Vivian Doan; Connor Snarskis; Matthew D. McEvoy; Karen Y. McCarthy; Gen Li; Warren S. Sandberg; Robert E. Freundlich
• Keywords: Medical record

Importance The time interval between COVID-19 infection and surgery is a potentially modifiable but understudied risk factor for postoperative complications. Objective To examine the association to after diagnosis of composite major cardiovascular morbidity events within 30 days surgery. Design, Setting, Participants This single-center, retrospective cohort study was conducted among 3997 adult patients (aged ≥18 years) with previous COVID-19, as documented by positive polymerase chain reaction test result, who were undergoing from January 1, 2020, December 6, 2021. Data obtained through Structured Query Language access an existing perioperative data warehouse. Statistical analysis performed March 29, 2022. Exposure Main Outcomes Measures primary outcome occurrence comorbidity, defined deep vein thrombosis, pulmonary embolism, cerebrovascular accident, myocardial injury, acute kidney death surgery, using multivariable logistic regression. Results A total (2223 [55.6%]; median age, 51.3 years [IQR, 35.1-64.4 years]; 667 [16.7%] African American or Black; 2990 [74.8%] White; 340 [8.5%] other race) included in study. 98 (IQR, 30-225 days). Major adverse identified 485 (12.1%). Increased associated decreased rate (adjusted odds ratio, 0.99 [per 10 days]; 95% CI, 0.98-1.00; P = .006). trend persisted 1552 had received at least 1 dose vaccine 0.98 0.97-1.00; .04). Conclusions Relevance suggests that increased experiencing morbidity. information should be used better inform risk-benefit discussions concerning optimal surgical timing outcomes history infection.