Association of Statin Use With Cancer- and Noncancer-Associated Survival Among Patients With Breast Cancer in Asia

• DOI: 10.1001/jamanetworkopen.2023.9515
• Publication Date: 2023-04-21T16:55:58Z
• Authors: Wei-Ting Chang; Hui-Wen Lin; Sheng-Hsiang Lin; Yi-Heng Li
• Keywords: Cohort Studies; Heart Failure; Asia; Humans; Female; Breast Neoplasms; Middle Aged; Hydroxymethylglutaryl-CoA Reductase Inhibitors; 3. Good health; Original Investigation; Aged; Retrospective Studies

Importance In addition to protective effects on the cardiovascular system, statins may reduce risk of breast cancer recurrence owing potential anti-inflammatory benefits. Given that patients with in Asia are relatively younger at diagnosis and most free from traditional factors, it is uncertain whether use can improve survival. Objective To investigate association statin cancer- noncancer-associated survival cancer. Design, Setting Participants This cohort study used Taiwanese National Health Insurance Research Database Cancer Registry identify diagnosed January 2012 December 2017. Age, stage, anticancer therapies, comorbidities, socioeconomic status, drugs were matched by propensity score method. Statistical analyses, including Cox proportional hazards models, performed June 2022 February 2023. The mean (SD) follow-up duration was 4.10 (2.96) years. Interventions Patients receiving within 6 months before compared those not statins. Main Outcomes Measures included death, heart failure, arterial venous events. Results Overall, 7451 (mean [SD] age, 64.3 [9.4] years) treated nonusers 65.8 [10.8] years). Compared nonusers, users had a significantly lower all-cause death (adjusted hazard ratio [HR], 0.83; 95% CI, 0.77-0.91; P < .001). Notably, reduction mainly attributed cancer-related HR, 0.75-0.92; Only small number died causes, ratios similar between nonusers. No significant differences observed outcomes, failure events, Using time-dependent analysis, also presented 0.28; 0.24-0.32; .001) than notably, even high-dose (HDS) non-HDS (HDS users: adjusted 0.84; 0.73-0.98; = .002; 0.79; 0.68-0.91; 001). Conclusions Relevance this Asian cancer, associated reduced cancer-associated rather death. Our findings provide evidence support cancer; however, randomized studies necessary.