Serum and Salivary IgG and IgA Response After COVID-19 Messenger RNA Vaccination

• DOI: 10.1001/jamanetworkopen.2024.8051
• Publication Date: 2024-04-23T15:01:59Z
• Authors: Guy Gorochov; Jacques Ropers; Odile Launay; Karim Dorgham; Omaira da Mata-Ja...; Said Lebbah; Christine Durier; Rebecca Bauer; Anne Radenne; Corinne Desaint; Louis-Victorien V...; Claire Rekacewicz; Marie Lachatre; Béatrice Parfait; Frédéric Batteux; Philippe Hupé; Läétitia Ninove; Maeva Lefebvre; Anne Conrad; Bertrand Dussol; Zoha Maakaroun-Ve...; Giovanna Melica; Jean-François Nic...; Renaud Verdon; Jean-Jacques Kila...; Paul Loubet; Catherine Schmidt...; Christian Dualé; Séverine Ansart; Elisabeth Botelho...; Jean-Daniel Lelièvre; Xavier de Lamball...; Marie-Paule Kieny; Eric Tartour; Stéphane Paul
• Keywords: Male; 0301 basic medicine; [SDV]Life Sciences [q-bio]; Paul Gorochov; Antibodies, Viral; Cohort Studies; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Original Investigation; [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases; [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases; Desaint; Vaccination; Middle Aged; France Gorochov; [SDV] Life Sciences [q-bio]; [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.IMM]Life Sciences [q-bio]/Immunology; Ninove; Female; France; 2019-nCoV Vaccine mRNA-1273; Adult; COVID-19 Vaccines; [SDV.IMM] Life Sciences [q-bio]/Immunology; Paul; Villejuif; Ropers; Kieny; Lebbah; Rekacewicz; 03 medical and health sciences; [SDV.IMM.VAC] Life Sciences [q-bio]/Immunology/Vaccinology; Tartour; Durier; Humans; Hupé; Saliva; Immunity, Mucosal; BNT162 Vaccine; Aged; Vieillard; Lachatre); INSERM SC10-US019; SARS-CoV-2; COVID-19; Launay Desaint Vieillard Rekacewicz Lachatre); INSERM SC10-US019 Villejuif France Gorochov Ropers Launay Durier Desaint Vieillard Lachatre Parfait Hupé Ninove Kieny Tartour Paul Gorochov Ropers Lebbah Desaint Parfait Tartour Paul; Immunoglobulin A; [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie; Immunoglobulin G; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology; Lachatre; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Launay; [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology; Parfait

Importance There is still considerable controversy in the literature regarding capacity of intramuscular messenger RNA (mRNA) vaccination to induce a mucosal immune response. Objective To compare serum and salivary IgG IgA levels among mRNA-vaccinated individuals with or without previous SARS-CoV-2 infection. Design, Setting, Participants In this cohort study, SARS-CoV-2–naive participants those infection were consecutively included CoviCompare P M mRNA trials followed up day 180 after either BNT162b2 (Pfizer-BioNTech) vaccine mRNA-1273 (Moderna) at beginning COVID-19 campaign (from February 19 June 8, 2021) France. Data analyzed from October 25, 2022, July 13, 2023. Main Outcomes Measures An ultrasensitive digital enzyme-linked immunosorbent assay was used for comparison spike-specific levels. Spike-specific secretory level also quantified selected times. Results A total 427 3 groups: prior who received 1 single dose (n = 120) 2 doses 172) 135). The median age 68 (IQR, 39-75) years, 228 (53.4%) men. saliva increased injections individuals. After vaccination, SARS-CoV-2–specific levels, normalized respect significantly higher infection, as compared most responsive recipients (median 155 × 10 −5 vs 37 29; 107 54 57; 104 70 [ < .001]). contrast, 1, BNT162b2-vaccinated group only 57 (36 49 .01]). Bona fide multimeric antigenic stimulations optical density, 0.36 [IQR, 0.16-0.63] 0.16 0.10-0.22]; .001). Conclusions Relevance findings study suggest that associated immunity but much lower than previously infected Further studies are needed determine association between specific prevention transmission.