Network Modelling Methods for Precision Medicine

• DOI: 10.1002/9781119716600.ch10
• Publication Date: 2022-11-18T21:28:58Z
• Authors: Elio Nushi; Victor‐Bogdan Pop...; Jose‐Angel Sanche...; Sergiu Ivanov; Eugen Czeizler; Ion Petre
• Keywords: Network controllability; Interaction network; Closeness

We discuss in this chapter several network modelling methods and their applicability to precision medicine. review centrality (degree centrality, closeness eccentricity betweenness eigenvector-based prestige) two systems controllability (minimum dominating sets structural controllability). demonstrate medicine on three multiple myeloma patient disease networks. Each consists of protein–protein interactions (PPI) built around a specific patient's mutated genes, the targets drugs used standard care myeloma, myeloma-specific essential genes. For each network, we how can be identify personalized, targeted drug combinations uniquely suited that patient.