Codelivery of a π–π Stacked Dual Anticancer Drug Combination with Nanocarriers for Overcoming Multidrug Resistance and Tumor Metastasis

• DOI: 10.1002/adfm.201603336
• Publication Date: 2016-09-28T11:22:08Z
• Authors: Xiao Wei; Yi Wang; Xiang Xiong; Xing Guo; Lei Zhang; Xiaobin Zhang; Shaobing Zhou
• Keywords: Nanocarriers

The multidrug resistance (MDR) of cancer cells is a major obstacle in chemotherapy and very few strategies are available to overcome it. Here, new strategy developed codeliver π–π stacked dual anticancer drug combination with an actively targeted, pH‐ reduction‐sensitive polymer micellar platform for combating tumor metastasis. In contrast other methods, two traditional chemotherapeutics, doxorubicin (DOX) 10‐hydroxycamptothecin complex aromatic conjugated structures, integrated into one delivery system via stacking interaction, which enables the released drugs evade recognition pumps due slight change drug's molecular structure. micelles exhibit active targeting DOX‐resistant human breast MCF‐7 (MCF‐7/ADR) have ability control release response microenvironmental stimuli cells. As result, codelivery displays high therapeutic efficacy MCF‐7/ADR model successfully prevents lung metastasis mechanism underlying reversal MDR investigated, results reveal that synergistic effect promotes mitochondria‐dependent apoptosis.