PDT‐Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy

• DOI: 10.1002/adfm.201804324
• Publication Date: 2018-08-29T18:20:30Z
• Authors: Lihuang Wu; Xiaojun Cai; Haofang Zhu; Junhua Li; Dongxu Shi; Dunfan Su; Dong Yue; Zhongwei Gu
• Keywords: Internalization

Abstract The precise delivery and controllable release of carbon monoxide (CO) to tumor tissues is an emerging anticancer therapy because CO in a high dose can be detrimental cell survival growth. However, gas limited by the gaseous nature that hinders its enrichment tissues. Here, novel photodynamic (PDT)‐driven system (CORM@G3DSP‐Ce6) integrates photosensitizer chlorin e6 (Ce6) H 2 O ‐sensitive releasing molecule CORM‐401 into peptide dendrimer‐based nanogels (G3DSP) described. Upon excitation with near‐infrared light, Ce6‐mediated photochemical effect not only promotes efficient cellular internalization CORM@G3DSP‐Ce6, but also triggers rapid intracellular from depleting produced during PDT. Importantly, PDT‐driven does impair generation capability singlet oxygen ( 1 ). As result, accompanied simultaneous large amounts cells, combination PDT offers significant synergistic effects superior therapeutic safety both vitro vivo.