Liquid Metal‐Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization

• DOI: 10.1002/adfm.202209413
• Publication Date: 2023-02-14T04:41:23Z
• Authors: Xiyu Zhu; Minghui Duan; Lin Zhang; Jiasheng Zhao; Sheng Yang; Rui Shen; Sen Chen; Linlin Fan; Jing Liu
• Keywords: Biocompatibility

Abstract The drug‐eluting microspheres that have been widely used in clinical treatments such as chemoembolization commonly suffer from inadequate drug loading and tracking difficulties. With inherent high density excellent biocompatibility, liquid metal (LM) has explored at the frontiers of medical imaging therapy. Herein, multifunctional (SA/LM/DOX) are reported with multimodal by adsorbing silanized LM particles on sulfonated agarose (SA), which capable heating accelerating release under an 808 nm near‐infrared (NIR) laser. negative SA can adsorb more positive drugs doxorubicin (DOX) up to 104 mg DOX per mL microspheres. It deserves be mentioned SA/LM/DOX function computed tomography (CT), magnetic resonance (MRI), B‐scan ultrasonography (US), significantly facilitate location during embolization process. In rabbit ear central artery embolization, these smoothly injected into intended vessel successfully blocked blood flow, eventually led necrosis ear. Overall, capacity contrast properties promising candidates developed new products for future medicine.