2D Ultrathin MXene‐Based Drug‐Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer

• DOI: 10.1002/adhm.201701394
• Publication Date: 2018-02-05T17:48:45Z
• Authors: Xiaoxia Han; Ju Huang; Han Lin; Zhigang Wang; Pan Li; Yu Chen
• Keywords: MXenes; Collateral damage

Abstract Two‐dimensional (2D) MXenes, as a new 2D functional material nanosystem, have been extensively explored for broad applications. However, their specific performance and applications in theranostic nanomedicine still rarely explored. This work reports on the drug‐delivery synergistic therapeutic efficiency of Ti 3 C 2 MXenes highly efficient tumor eradication. These not only possess high drug‐loading capability 211.8%, but also exhibit both pH‐responsive near infrared laser‐triggered on‐demand drug release. Especially, based photothermal‐conversion they further eradication by photothermal ablation chemotherapy, which has systematically demonstrated vitro vivo. desirable contrast agents photoacoustic imaging, showing potential diagnostic‐imaging guidance monitoring during therapy. The vivo histocompatibility easy excretion out body evaluated demonstrated, biosafety clinical translation. paves way broadening biomedical where can exert functionality therapy, especially combating cancer.