Conceptually Novel Black Phosphorus/Cellulose Hydrogels as Promising Photothermal Agents for Effective Cancer Therapy

• DOI: 10.1002/adhm.201701510
• Publication Date: 2018-03-06T09:17:57Z
• Authors: Chenyang Xing; Shiyou Chen; Meng Qiu; Xin Liang; Quan Liu; Qingshuang Zou; Zhongjun Li; Zhongjian Xie; Dou Wang; Biqin Dong; Liping Liu; Dianyuan Fan; Han Zhang
• Keywords: Biocompatibility; Black Phosphorus; Bacterial Cellulose; Natural polymers; Photothermal effect

Abstract Black phosphorus (BP) has recently emerged as an intriguing photothermal agent in therapy (PTT) against cancer by virtue of its high efficiency, biocompatibility, and biodegradability. However, naked BP is intrinsically characterized easy oxidation (or natural degradation) sedimentation inside the tumor microenvironment, leading to a short‐term therapeutic inhomogeneous effect. Development BP‐based nanocomposites for PTT therefore remains challenging. The present work demonstrates that green injectable composite hydrogels based on cellulose nanosheets (BPNSs) are great efficiency cancer. resultant cellulose/BPNS‐based hydrogel possesses 3D networks with irregular micrometer‐sized pores thin, strong cellulose‐formed walls exhibits excellent response, enhanced stability, good flexibility. Importantly, this nanoplatform totally harmless biocompatible both vivo vitro. This may facilitate development BP–polymer‐based agents form biomedical‐related clinic applications.