A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires

• DOI: 10.1002/adhm.201801187
• Publication Date: 2019-02-09T08:01:26Z
• Authors: Yimu Zhao; Erika Yan Wang; Locke Huyer Daven...; Yin Liao; Keith Yeager; Gordana Vunjak‐No...; Milica Radisic; Boyang Zhang
• Keywords: Polydimethylsiloxane

Abstract Due to escalating drug developmental costs and limitations of cardiotoxicity screening, there is an urgent need develop robust in vitro 3D tissue culture platforms that can both facilitate the human cardiac tissues provide noninvasive functional readouts predictive clinical settings. However, such commonly require complex fabrication procedures are difficult scale up high‐throughput testing platforms. Here, innovative multimaterial processing into a scalable platform proposed format 96‐well plate. Three classes materials integrated platform. An array soft elastic microwires used as anchors for formation well sensors recording contraction. Conductive carbon electrodes embedded plate drive electrical stimulation maturation pace contraction during testing. The bulk device made rigid polystyrene plastic eliminate drug‐absorbing polydimethylsiloxane (PDMS). has higher throughput than current state‐of‐the‐art devices, at significantly reduced cost manufacturing production.