A Hydrogel Microneedle Patch for Point‐of‐Care Testing Based on Skin Interstitial Fluid

• DOI: 10.1002/adhm.201901201
• Publication Date: 2020-01-20T08:58:39Z
• Authors: Rongyan He; Yan Niu; Zedong Li; Ang Li; Huayuan Yang; Feng Xu; Fei Li
• Keywords: Interstitial fluid; Point-of-Care Testing

Abstract Skin interstitial fluid (ISF) holds great potential as a highly desirable sample resource for point‐of‐care testing (POCT), where the key is to effectively collect target biomarkers from ISF. Hydrogel microneedle patch has promise ISF extraction. However, it challenging recover extracted skin in hydrogel patches an easy‐administrated, fast, and bulky instrument‐free manner. Herein, made of polyvinyl alcohol (PVA) chitosan (CS) POCT based on developed. The phase transition property PVA/CS makes microneedles stiff when dry, which beneficial easily penetrate into skin. Meanwhile, porous microstructure offers good swelling ability extraction thermal degradation PVA convenient quickly efficiently patch. capability this platform applications further demonstrated by successful detections typical collected mimetic monitoring glucose level rabbit skins during day. developed advantages recovery biomarkers, thus presenting powerful ISF‐based applications.