Biodegradable Metal–Organic Framework‐Based Microrobots (MOFBOTs)

• DOI: 10.1002/adhm.202001031
• Publication Date: 2020-09-18T07:31:26Z
• Authors: Anastasia Terzopo...; Xiaopu Wang; Xiang‐Zhong Chen; Mario Palacios‐Co...; Carlos Pujante; Javier Herrero‐Ma...; Xiao‐Hua Qin; Jordi Sort; Andrew J. deMello; Bradley J. Nelson; Josep Puigmartí‐Luis; Salvador Pané
• Keywords: zeolitic imidazolate frameworks; 02 engineering and technology; 01 natural sciences; biodegradation; 0104 chemical sciences; 3. Good health; metal–organic frameworks; Drug Delivery Systems; Magnetic Fields; Doxorubicin; Neoplasms; drug delivery; Humans; biodegradation; drug delivery; metal–organic frameworks; microrobots; zeolitic imidazolate frameworks; 0210 nano-technology; microrobots; Metal-Organic Frameworks

Microrobots and metal-organic frameworks (MOFs) have been identified as promising carriers for drug delivery applications. While clinical applications of microrobots are limited by their low loading efficiencies the poor degradability materials used fabrication, MOFs lack motility targeted capabilities. The combination these two fields marks beginning a new era; MOF-based small-scale robots (MOFBOTs) biomedical Yet, biodegradability is major hurdle in field micro- nanoswimmers including robots. Here, highly integrated MOFBOT that able to realize magnetic locomotion, delivery, selective degradation cell cultures reported first time. MOF investigations does not only allow superior chemotherapeutic drugs controlled release via pH-responsive but it also enables locomotion enzymatically biodegradable gelatin-based helical under fields. observed after weeks, when all its components fully degrade. Additionally, studies performed cancer show reduced viability upon Doxorubicin within short time frames. This system opens avenues