Nanodroplet‐Coated Microbubbles Used in Sonothrombolysis with Two‐Step Cavitation Strategy

• DOI: 10.1002/adhm.202202281
• Publication Date: 2022-11-26T14:24:57Z
• Authors: Yunfan Pan; Yongjian Li; Yan Li; Xiaobing Zheng; Chenghong Zou; Jiang Li; Haosheng Chen
• Keywords: 0106 biological sciences; Mice; Microbubbles; Fibrinolytic Agents; Ultrasonic Therapy; Animals; Thrombosis; 01 natural sciences; Ultrasonography

Abstract Thrombosis is a major cause of morbidity and mortality sonothrombolysis promising method for its treatment. However, the slow diffusion thrombolytic agents into thrombus results in recanalization. Here, nanodroplet‐coated microbubbles (NCMBs) are designed fabricated two‐step cavitation strategy used to accelerate thrombolysis. The first NCMBs, collapse induced by low frequency ultrasound, drives nanodroplets on shell thrombus, while second cavitation, phase‐change volume expansion drug‐loaded triggered high loosens sono‐porosity effect. This NCMBs verified using fibrin agarose model, where rapid observed. Furthermore, reach much higher thrombolysis efficiency both vitro proof‐of‐concept experiments performed with living mice. medicines carrier efficient drug delivery.