Targeting Ligand Independent Tropism of siRNA‐LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells

• DOI: 10.1002/adhm.202202670
• Publication Date: 2023-01-09T03:36:42Z
• Authors: Cheng Lin; Asmaa Mostafa; Alexander Jans; Justina Clarinda ...; Mohamed Ramadan M...; Emiel P. C. Van d...; Christian Trautwein; Matthias Bartneck
• Keywords: 0301 basic medicine; transcriptomics; 03 medical and health sciences; immune cells; proteomics; imaging of siRNA-LNP; siRNA-LNP; hepatocytes; in vivo imaging

Hepatic clearance of lipid nanoparticles (LNP) with encapsulated nucleic acids restricts their therapeutic applicability. Therefore, tools for regulating hepatic are high interest acid delivery. To this end, work employs wild-type (WT) and low-density lipoprotein receptor (Ldlr)