Guiding Fibroblast Activation Using an RGD‐Mutated Heparin Binding II Fragment of Fibronectin for Gingival Titanium Integration

• DOI: 10.1002/adhm.202203307
• Publication Date: 2023-04-26T23:58:48Z
• Authors: Aina Heras‐Parets; Maria‐Pau Ginebra; Jose Maria Manero; Jordi Guillem‐Marti
• Keywords: Fragment (logic)

Abstract The formation of a biological seal around the neck titanium (Ti) implants is critical for ensuring integration at gingival site and preventing bacterial colonization that may lead to periimplantitis. This process guided by activated fibroblasts, named myofibroblasts, which secrete extracellular matrix (ECM) proteins ECM‐degrading enzymes resolving wound. However, in some cases, Ti not able attract activate fibroblasts sufficient extent, compromise success implant. Fibronectin (FN) an ECM component found wounds guide soft tissue healing through adhesion cells attraction growth factors (GFs). clinical use FN functionalized problematic because difficult obtain, sensitive degradation. Herein, functionalizing with modified recombinant heparin binding II (HBII) domain FN, mutated include Arg‐Gly‐Asp (RGD) sequence promoting both fibroblast GF attraction, aimed at. HBII‐RGD stimulate adhesion, spreading, proliferation, migration, activation greater extent than native HBII, reaching values closer those full‐length suggesting it might induce sealing.