Pathogen‐Targeting Bimetallic Nanozymes as Ultrasonic‐Augmented ROS Generator against Multidrug Resistant Bacterial Infection

• DOI: 10.1002/adhm.202300449
• Publication Date: 2023-07-11T11:39:48Z
• Authors: Hong Yao; Ruixue Zhou; Jiaming Wang; Yongbin Wei; Shihong Li; Zhenzhong Zhang; Xiang‐Dang Du; Sixuan Wu; Jinjin Shi

Abstract Clinical treatment of multidrug resistant (MDR) pathogens‐induced infection is emerging as a growing challenge in global public health due to the limited selection clinically available antibiotics. Nanozymes artificial enzymes that mimicked natural enzyme‐like activities, are received great attention for combating MDR pathogens. However, relatively deficient catalytic activity infectious microenvironment and inability precisely targeting pathogen restrains their clinical anti‐MDR applications. Here, pathogen‐targeting bimetallic BiPt nanozymes nanocatalytic therapy against reported. Benefiting from electronic coordination effect, exhibit dual‐enzymatic including peroxidase‐mimic oxidase‐mimic activities. Moreover, efficiency can be efficiently increased 300‐fold by ultrasound under inflammatory microenvironment. Notably, nanozyme further cloaked with platelet‐bacteria hybrid membrane (BiPt@HMVs), thus presenting excellent homing effect sites precise homologous pathogen. By integrating accurate highly efficient catalytic, BiPt@HMVs eliminate carbapenem‐resistant Enterobacterales methicillin‐resistant Staphylococcus aureus osteomyelitis rats model, muscle‐infected mice pneumonia model. The work provides an alternative strategy based on addressing bacteria‐induced infections.