Bivalent Gadolinium Ions Forming Injectable Hydrogels for Simultaneous In Situ Vaccination Therapy and Imaging of Soft Tissue Sarcoma

• DOI: 10.1002/adhm.202300877
• Publication Date: 2023-08-12T00:13:38Z
• Authors: Chun Wang; Yuanhao Jing; Wenting Yu; Jie Gu; Zijian Wei; Anni Chen; Ying‐Tzu Yen; Xiaowen He; Lanqi Cen; Aoxing Chen; Xueru Song; Yirong Wu; Lixia Yu; Gaojian Tao; Baorui Liu; Shoufeng Wang; Bin Xue; Rutian Li
• Keywords: Mice; Doxorubicin; Vaccination; Animals; Hydrogels; Gadolinium; Sarcoma; Research Articles; 3. Good health

Doxorubicin (DOX) is the classic soft tissue sarcomas (STS) first-line treatment drug, while dose-dependent myelosuppression and cardiotoxicity limit its application in clinic. This research intends to apply DOX, which also an inducer of immunogenic cell death as a part for "in situ vaccination" conjointly uses PD-1 inhibitors enhance antitumor efficacy. In order achieve sustained vaccination effect real-time monitoring distribution vivo, forming injectable hydrogel platform with function visualization established local delivery. The synthesized by hyaluronic acid-dopamine coordinated gadolinium ions (Gd