Transdermal Sustained Release Properties and Anti‐Photoaging Efficacy of Liposome‐Thermosensitive Hydrogel System

• DOI: 10.1002/adhm.202301933
• Publication Date: 2023-08-23T00:34:06Z
• Authors: Sijie Wu; Gaodan Liu; Ping Shao; Xingyu Lin; Jiahao Yu; Hanchi Chen; Huiliang Li; Simin Feng
• Keywords: Photoaging

Abstract Drug delivery systems have become a research priority in the biomedical field. The incorporation of liposomes to hydrogels further forms more robust multifunctional for effective and sustained topical drug delivery. In this study, carboxymethyl‐modified chitosan/hyaluronic acid (CMC/HA, CMH) thermosensitive hydrogel is developed transdermal liposomes. Hydrogels are crosslinked by hydrogen bonding, hydrophobic interaction electrostatic interaction. gel properties can be regulated substitution degree (DS), when DS = 18.20 ± 0.67% (CMH2), temperature 37.8 °C, allowing rapid gelation at body (315 s). Moreover, CMH2 has suitable spreadability (17.7–57.2 cm 2 ), viscosity (2133.4 mPa s) porous structure, which facilitated its adhesion application on skin retard release, release rate ascorbyl glucoside (AA2G) 33.92–49.35% 24 h. Hydrogel avoids clearance from improved retention, achieving long‐term bioactive components. Liposome‐hydrogel system efficiently promotes anti‐photoaging effect AA2G skin, reducing epidermal thickness, melanin deposition lipid oxidative damage increasing collagen density. Therefore, liposome‐hydrogel proposed as