The Design of a Heterocellular 3D Architecture and its Application to Monitoring the Behavior of Cancer Cells in Response to the Spatial Distribution of Endothelial Cells

• DOI: 10.1002/adma.201200687
• Publication Date: 2012-08-24T08:35:14Z
• Authors: Wonjae Lee; Jon Park
• Keywords: 0301 basic medicine; Cell Survival; Endothelial Cells; Hydrogels; Cell Communication; Rats; 3. Good health; 03 medical and health sciences; Polylactic Acid-Polyglycolic Acid Copolymer; Cell Line, Tumor; Neoplasms; Human Umbilical Vein Endothelial Cells; Animals; Humans; Microtechnology; Lactic Acid; Polyglycolic Acid

The spatial cell distribution is one of the critical features for governing cellular interactions and their consequent behaviors. Here we suggest a novel method building hierarchical structure by stacking cellattached microplate structures with specific configurations within hydrogel layers. This applied to reconstruction 3D architecture liver lobule development an experimental model various phases cancer angiogenesis.