Biomolecular Materials: Self‐Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T‐Cell Epitope Promote a Protective Immune Response In Vivo (Adv. Mater. 28/2012)

• DOI: 10.1002/adma.201290170
• Publication Date: 2012-07-19T06:47:21Z
• Authors: Matthew Black; Amanda Trent; Yulia Kostenko; Joseph Saeyong Lee; Colleen Olive; Matthew Tirrell
• Keywords: 01 natural sciences; 0104 chemical sciences

Peptide amphiphiles, synthesized by conjugating bioactive peptides to hydrophobic dialkyl tails, have been developed as a modular platform for immunotherapy, discussed M. Black, A. Trent and co-workers on page 3845. The image (by Peter Allen at UCSB) illustrates how the amphiphiles self-assemble into dynamic micellar structures in which many copies of peptide antigens are presented micelle periphery. Unlike alone, micelles, without any additional adjuvant, promote peptide-specific immune responses vivo.