Scalable Manufacture of Built‐to‐Order Nanomedicine: Spray‐Assisted Layer‐by‐Layer Functionalization of PRINT Nanoparticles

• DOI: 10.1002/adma.201302025
• Publication Date: 2013-07-01T11:35:30Z
• Authors: Stephen W. Morton; Kevin P. Herlihy; Kevin E. Shopsowitz; Zhou J. Deng; Kevin S. Chu; Charles J. Bowerman; Joseph M. DeSimone; Paula T. Hammond
• Keywords: Surface Modification; Layer by layer; Deposition

Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform functional nanotechnologies with precise control over composition, size, shape, surface functionality. A modular tunable approach towards design of built-to-order nanoparticle systems, spray coating on particles is demonstrated achieve technologies capable targeted interactions cancer cells for applications in drug delivery.