Controlled Cell Adhesion on Poly(dopamine) Interfaces Photopatterned with Non‐Fouling Brushes

• DOI: 10.1002/adma.201302492
• Publication Date: 2013-09-03T08:53:06Z
• Authors: Cesar Rodriguez‐E...; Corinna M. Preuss; Basit Yameen; Ognen Pop‐Georgie...; Michael Bachmann; Jan O. Mueller; Michael Bruns; Anja S. Goldmann; Martin Bastmeyer; Christopher Barne...
• Keywords: green fluorescent protein; Indoles; Polymers; 01 natural sciences; Polyethylene Glycols; animal; genetics; rat; macrogol derivative; Amines; vasodilator-stimulated phosphoprotein; Antifouling polymers; info:eu-repo/classification/ddc/570; photoligation; biology; Microfilament Proteins; article; antifouling polymer brushes; acrylic acid derivative; cell line; actin binding protein; phosphoprotein; Life sciences; nitrile imine-mediated tetrazole-ene cycloaddition (NITEC); Acrylates; ddc:570; Micro patterning; 570; Silicon; polymer; Recombinant Fusion Proteins; Green Fluorescent Proteins; Neurophysiology; chemistry; Cell Line; Cell Adhesion; Animals; poly(dopamine); poly(oligoethylene glycol methyl ether acrylate); indole derivative; polydopamine; hybrid protein; Cyanides; Cell adhesion; silicon; 540; Phosphoproteins; micropatterning; Rats; 0104 chemical sciences; biosynthesis; cell adhesion molecule; metabolism; Cell Adhesion Molecules; vasodilator stimulated phosphoprotein

Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-based phototriggered surface encoding protocol. The antifouling brushes were photopatterned on PDA surfaces, leading cells to form confluent layers in the non-irradiated sections, while no adhesion occurred on the brushes resulting in a remarkably precise cell pattern. The presented strategy paves the way for the design of tailor-made patterned cell interfaces.