One Step Creation of Multifunctional 3D Architectured Hydrogels Inducing Bone Regeneration

• DOI: 10.1002/adma.201404787
• Publication Date: 2015-01-20T12:38:08Z
• Authors: Axel T. Neffe; Benjamin F. Pierce; Giuseppe Tronci; Nan Ma; Erik Pittermann; Tim Gebauer; Oliver Frank; Michael Schossig; Xun Xu; Bettina M. Willie; Michèle Forner; Agnes Ellinghaus; Jasmin Lienau; Georg N. Duda; Andreas Lendlein
• Keywords: 0301 basic medicine; Bone Regeneration; Cell Survival; Biocompatible Materials; Cell Differentiation; Hydrogels; Mesenchymal Stem Cells; Fibroblasts; Elasticity; Cell Line; 03 medical and health sciences; Physical Stimulation; Absorbable Implants; Materials Testing; Cell Adhesion; Animals; Gelatin; Humans; Female; ddc:610; Femur; Bony Callus; Cells, Cultured

Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.