Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

• DOI: 10.1002/adma.201502697
• Publication Date: 2016-03-22T14:13:45Z
• Authors: Mohammad Mahdi Ha...; Shahrouz Taranejoo; Erfan Dashtimoghadam; Ghasem Bahlakeh; Fatemeh Sadat Majedi; Jules John VanDer...; Mohsen Janmaleki; Fatemeh Sharifi; Arnaud Bertsch; Kerry Hourigan; Lobat Tayebi; Philippe Renaud; Karl I. Jacob
• Keywords: Drug Carriers; Microfluidics; Hydrogen-Ion Concentration; 01 natural sciences; 3. Good health; 0104 chemical sciences; Drug Liberation; Drug Delivery Systems; Dentistry; Colonic Neoplasms; Humans; Nanoparticles

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.