Few‐Layer Graphdiyne Nanosheets Applied for Multiplexed Real‐Time DNA Detection

• DOI: 10.1002/adma.201606755
• Publication Date: 2017-03-10T16:51:07Z
• Authors: Nargish Parvin; Quan Jin; Yanze Wei; Ranbo Yu; Bing Zheng; Ling Huang; Ying Zhang; Lianhui Wang; Hua Zhang; Mingyuan Gao; Huijun Zhao; Wenping Hu; Yuliang Li; Dan Wang
• Keywords: double stranded DNA; graphdiyne nanosheets; fluorescence quenching; DNA, Single-Stranded; Biosensing Techniques; DNA; 02 engineering and technology; real-time detection; Nanostructures; Physical sciences; Engineering; Spectrometry, Fluorescence; Chemical sciences; biosensing; Materials engineering not elsewhere classified; 0210 nano-technology

Despite recent progress in 2D nanomaterials-based biosensing, it remains challenging to achieve sensitive and high selective detection. This study develops few-layer graphdiyne (GD) nanosheets (NSs) that are used as novel sensing platforms for a variety of fluorophores real-time detection DNA with low background signal-to-noise ratio, which show distinguished fluorescence quenching ability different affinities toward single-stranded double-stranded DNA. Importantly, the first time, GD NSs-based multiplexed sensor is developed.