Near‐Infrared Upconversion Mesoporous Cerium Oxide Hollow Biophotocatalyst for Concurrent pH‐/H2O2‐Responsive O2‐Evolving Synergetic Cancer Therapy

• DOI: 10.1002/adma.201704833
• Publication Date: 2018-01-10T07:18:45Z
• Authors: Chi Yao; Wenxing Wang; Peiyuan Wang; Mengyao Zhao; Xiaomin Li; Fan Zhang
• Keywords: Hypoxia; Photon Upconversion; Cerium oxide; Tumor Hypoxia

Tumor hypoxia is typically presented in the central region of solid tumors, which mainly caused by an inadequate blood flow and oxygen supply. In conventional treatment hypoxic human not only oxygen-dependent photodynamic therapy (PDT), but also antitumor drug-based chemotherapy, considerably limited. The use direct delivering approach with PDT or chemotherapy may potentiate reactive species (ROS)-mediated cytotoxicity drug toward normal tissues. Herein, a synergetic one-for-all mesoporous cerium oxide upconversion biophotocatalyst developed to achieve intratumorally endogenous H2 O2 -responsive self-sufficiency near-infrared light controlled simultaneously for overcoming cancer. Furthermore, sufficient plays important role chemotherapeutic drug-resistant cancer hypoxia, therefore inducing tumor cell apoptosis significantly.