In Situ Self‐Assembling Micellar Depots that Can Actively Trap and Passively Release NO with Long‐Lasting Activity to Reverse Osteoporosis

• DOI: 10.1002/adma.201705605
• Publication Date: 2018-04-17T17:28:00Z
• Authors: Yu‐Jung Lin; Chun‐Chieh Chen; Nai‐Wen Chi; Trang Nguyen; Hung‐Yun Lu; Dang Nguyen; Po‐Liang Lai; Hsing‐Wen Sung
• Keywords: Trap (plumbing)

Treatment with exogenous nitric oxide (NO) donors is regarded as being effective against osteoporosis. However, NO has a short half-life, limiting its clinical usefulness. To overcome this limitation, an injectable microparticle (MP) system developed that consists of phase-change materials capric acid (CA) and octadecane, encapsulates donor. The therapeutic efficacy the MPs evaluated in ovariectomized (OVX) rats Upon subcutaneous administration, undergo phase transition, leaching out donor generating bubbles are instantly covered by layer tightly packed CA surfactant molecules, forming micellar depots. situ self-assembling depots can actively protect bubbles, prolonging their while entrapped may passively diffuse through over time, performing long-lasting function, reversing OVX-induced It possible to use concept herein expand effect diverse range applications.