A Biomimetic Non‐Antibiotic Approach to Eradicate Drug‐Resistant Infections

• DOI: 10.1002/adma.201806024
• Publication Date: 2018-12-27T10:42:52Z
• Authors: Yu Zhao; Qianqian Guo; Xiaomei Dai; Xiaosong Wei; Yunjian Yu; Xuelei Chen; Chaoxing Li; Zhiqiang Cao; Xinge Zhang
• Keywords: Mice, Inbred BALB C; Nanotubes; Lactose; Hyperthermia, Induced; Phototherapy; 01 natural sciences; Abscess; Gold Compounds; 3. Good health; 0104 chemical sciences; Mice; Polymethacrylic Acids; A549 Cells; Biomimetic Materials; Biofilms; Lectins; Drug Resistance, Bacterial; Escherichia coli; NIH 3T3 Cells; Pneumonia, Bacterial; Animals; Humans; Adhesins, Bacterial

The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to be properly addressed. In particular, for drug-resistant strains, limited medication is available. An in vivo pneumonia model induced a clinically isolated aminoglycoside resistant strain of P. developed. Tobramycin treating found ineffective inhibit or eliminate this strain. Here, newly developed non-antibiotics based nanoformulation plus near-infrared (NIR) photothermal treatment shows remarkable antibacterial efficacy pneumonia. novel formulation contains 50-100 nm long nanorods decorated with two types glycomimetic polymers specifically block bacterial LecA and LecB lectins, respectively, which are essential biofilm development. Such 3D display heteromultivalent glycomimetics on large scale inspired the natural strengthening mechanism carbohydrate-lectin interaction that occurs when bacteria initially infects host. This most efficient inhabitation killing against infection, through lectin blocking near-infrared-light-induced effect gold nanorods, respectively. Collectively, biomimetic design combined capability expected an alternative strategy ever-threatening infectious diseases known antibiotics have failed.