Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity

• DOI: 10.1002/adma.201900795
• Publication Date: 2019-06-21T06:41:02Z
• Authors: Guangna Liu; Xiao Zhao; Yinlong Zhang; Junchao Xu; Jiaqi Xu; Yao Li; Huan Min; Jian Shi; Ying Zhao; Jingyan Wei; Jing Wang; Guangjun Nie
• Keywords: Blood Platelets; Mice, Inbred BALB C; Cell Survival; Phosphatidylethanolamines; Cell Membrane; Antineoplastic Agents; 02 engineering and technology; Hydrogen-Ion Concentration; 3. Good health; Biomimetic Materials; Doxorubicin; Cell Line, Tumor; Liposomes; Animals; Humans; Nanoparticles; Female; Tissue Distribution; 0210 nano-technology

Biomimetic camouflage, i.e., using natural cell membranes for drug delivery, has demonstrated advantages over synthetic materials in both pharmacokinetics and biocompatibility, so represents a promising solution the development of safe nanomedicine. However, only limited efforts have been dedicated to engineering such camouflage endow it with optimized or additional properties, particular properties critical "smart" delivery system, as stimuli-responsive release. A pH-responsive biomimetic "platesome" specific tumors tumor-triggered release is described. This platesome nanovehicle constructed by merging platelet functionalized liposomes exhibits enhanced tumor affinity, due its membrane-based selectively releases cargo response acidic microenvironment lysosomal compartments. In mouse cancer models, shows significantly better antitumor efficacy than nanoformulations based on without pH responsiveness those traditional pH-sensitive liposomes. convenient way incorporate features into nanoparticles described, demonstrating potential engineered camouflages new generation biocompatible efficient nanocarriers.