A Transformable Amphiphilic and Block Polymer−Dendron Conjugate for Enhanced Tumor Penetration and Retention with Cellular Homeostasis Perturbation via Membrane Flow

• DOI: 10.1002/adma.202200048
• Publication Date: 2022-02-16T09:53:43Z
• Authors: Lei Gu; Zhenyu Duan; Xiaoting Chen; Xiaoling Li; Qiang Luo; Apanpreet Bhamra; Dayi Pan; Hongyan Zhu; Xiaohe Tian; Rongjun Chen; Zhongwei Gu; Hu Zhang; Zhiyong Qian; Qiyong Gong; Kui Luo
• Keywords: Conjugate; Dissipative particle dynamics

Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design drug delivery systems. Herein, a polymer-dendron conjugate, POEGMA-b-p(GFLG-Dendron-Ppa) (GFLG-DP), is presented, which allows cathepsin-B-triggered stealthy-to-sticky structural transformation. The compositions ratios are optimized dissipative particle dynamics simulations. GFLG-DP displays tumor-specific transformation the consequently released dendron-Ppa found to effectively accumulate on cell membrane. interaction between membrane results intracellular intercellular transport via flow, thus achieving efficient deep prolonged solid tissues. Meanwhile, with endoplasmic reticulum disrupts homeostasis, making cells more vulnerable susceptible photodynamic therapy. This platform represents versatile approach augmenting efficacy nanomedicine manipulation its interactions