Integrated Urinalysis Devices Based on Interface‐Engineered Field‐Effect Transistor Biosensors Incorporated With Electronic Circuits

• DOI: 10.1002/adma.202203224
• Publication Date: 2022-07-19T23:48:25Z
• Authors: Yanbing Yang; Jingfeng Wang; Wanting Huang; Guojia Wan; Miaomiao Xia; Duo Chen; Yun Zhang; Yiming Wang; Fuding Guo; Jie Tan; Huageng Liang; Bo Du; Lilei Yu; Weihong Tan; Xiangfeng Duan; Quan Yuan
• Keywords: Biosensing Techniques; Cystoscopy; 02 engineering and technology; Urinalysis; 6. Clean water; 3. Good health; Urinary Bladder Neoplasms; Biomarkers, Tumor; Humans; Electronics; Neoplasm Recurrence, Local; Zinc Oxide; 0210 nano-technology

Urinalysis is attractive in non-invasive early diagnosis of bladder cancer compared with clinical gold standard cystoscopy. However, the trace tumor biomarkers urine and particularly complex environment pose significant challenges for urinalysis. Here, a clinically adoptable urinalysis device that integrates molecular-specificity indium gallium zinc oxide field-effect transistor (IGZO FET) biosensor arrays, control panel, an internet terminal directly analyzing five bladder-tumor-associated proteins samples, reported classification. The IGZO FET biosensors engineered sensing interfaces provide high sensitivity selectivity identification environment. Integrating machine-learning algorithm, this can identify accuracy 95.0% cohort 197 patients 75 non-bladder individuals, distinguishing stages overall 90.0% assessing recurrence after surgical treatment. defines robust technology remote healthcare personalized medicine.