3D Printed Titanium Scaffolds with Bi‐Directional Gradient QK‐Functionalized Surface

• DOI: 10.1002/adma.202406421
• Publication Date: 2025-01-15T10:06:36Z
• Authors: Xiaoyun Sun; Ru Zhong; Congcong Wu; Silin Ye; Haipeng Yuan; Zhou Fang; Junjian Chen; Delin Cheng; Lijing Hao; Lei Chu; Lin Wang
• Keywords: 3d printed; Surface Modification

3D printed titanium scaffold has promising applications in orthopedics. However, the bioinert presents challenges for promoting vascularization and tissue growth within porous stable osteointegration. In this study, a modular is created using printing gradient-surface strategy to immobilize QK peptide on surface with bi-directional gradient distribution. This design featured high density interior low both ends, aiming induce cell migration from ends subsequently enhance osteointegration scaffold. vitro results showed that besides inherent bioactivity, distribution of positively correlated endothelial promoted angiogenesis. vivo assay was performed by segmental bone defect model rabbit spine repair sheep. Various staining Micro-CT demonstrated compared uniformly QK-functionalized surface, (Ti-G) significantly encouraged new toward scaffold, facilitated angiogenesis study provides an effective enhancing bioactivity peptide-functionalized scaffolds through concept gradients, holds potential various scaffolds.