Tissue Mimetic Membranes for Healing Augmentation of Tendon–Bone Interface in Rotator Cuff Repair

• DOI: 10.1002/adma.202407358
• Publication Date: 2025-01-31T11:42:22Z
• Authors: Yuwei Zhu; Bingyang Dai; Shian Zhang; Jun Liu; Shunxiang Xu; Weiyang Liu; Xin Chen; Haozhi Zhang; Quan Li; Florence Ou‐Suet ...; Weiguo Li; Chunyi Wen; Ling Qin; Jiankun Xu; To Ngai
• Keywords: Interface (matter)

The globally prevalent rotator cuff tear has a high re-rupture rate, attributing to the failure reproduce interfacial fibrocartilaginous enthesis. Herein, hierarchically organized membrane is developed that mimics heterogeneous anatomy and properties of natural enthesis finely facilitates reconstruction tendon-bone interface. A biphasic consisting microporous layer mineralized fibrous constructed through non-solvent induced phase separation (NIPS) strategy followed by co-axial electrospinning procedure. Cationic kartogenin (KGN)-conjugated nanogel (nGel-KGN) osteo-promotive struvite are incorporated within membranes in region-specific manner. During vivo repair, nGel-KGN-functionalized adjacent tendon which intends suppress scar tissue formation at lesion simultaneously heightens chondrogenesis. Meanwhile, struvite-containing covers tubercula minus enhance stem cell aggregation bony ingrowth. Such tissue-specific features spatiotemporal release behaviors contribute effective guidance specific defect-healing events transitional region, further leading remarkably promoted regenerative outcome terms formation, collagen fiber alignment, optimized functional motion cuff. These findings render novel biomimetic as promising material for clinical repair.