Photocatalytic Carbon Dots‐Triggered Pyroptosis for Whole Cancer Cell Vaccines

• DOI: 10.1002/adma.202408685
• Publication Date: 2024-08-12T09:19:04Z
• Authors: Quansheng Cheng; Tesen Zhang; Qingcheng Wang; Xue Wu; Lingyun Li; Runxing Lin; Yinning Zhou; Songnan Qu
• Keywords: Pyroptosis; Cancer Immunotherapy

Abstract Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial for tumor immunotherapy. Pyroptotic cells, due to their highly immunogenic properties, present a promising avenue the development of WCCV. However, successful WCCV based on pyroptotic cells yet be accomplished. Here, facile strategy that utilized photocatalytic carbon dots (CDs) induce pyroptosis fabricating reported. Photocatalytic CDs are capable generating substantial amounts hydroxyl radicals can effectively decrease cytoplasmic pH values under white light irradiation. This process efficiently triggers through reactive oxygen species (ROS)‐mitochondria‐caspase 3‐gasdermin E pathway proton motive force‐driven mitochondrial ATP synthesis pathway. Moreover, in vitro, these CDs‐induced (PCIP) hyperactivate macrophage (M0–M1) upregulation major histocompatibility complex class II expression. In vivo, PCIP induced specific immune‐preventive effects melanoma breast mouse models anticancer immune memory, demonstrating effective work provides novel insights inducing bridges gap fabrication cells.