Electrochemical Insertion of Zinc Ions into Self‐Organized Titanium Dioxide Nanotube Arrays to Achieve Strong Osseointegration with Titanium Implants

• DOI: 10.1002/admi.202200312
• Publication Date: 2022-04-21T04:11:10Z
• Authors: Hang Zhao; Wenhan Wang; Feng Liu; Ying Kong; Xin Chen; Liang Wang; Wenjun Ma; Chao Liu; Yuanhua Sang; Xingbang Wang; Shuhua Wang; Hong Liu
• Keywords: Titanium Dioxide; Biocompatibility

Abstract The construction of titanium dioxide (TiO 2 ) nanotube arrays on the surface metallic has been demonstrated as a practical approach for improving biocompatibility orthopedic implants. However, it remains challenge to form strong bonds between such TiO ‐based systems and surrounding bone due their lack osseointegration ability. Herein, inspired by intercalation mechanism rechargeable batteries, feasible electrochemical strategy is developed insert high‐concentration bioactive zinc ions into lattices with controlled release performance without nanostructure collapse. ion‐inserted give implants that exhibit excellent osteogenesis properties synergistic effect topography ions. Using proposed insertion technique, prepared substrates can trigger osteogenic differentiation marrow‐derived mesenchymal stem cells (MSCs) in vitro subsequent implant‐to‐bone vivo. This study establishes general method enhance bioactivity implants, thereby providing promising tissue repair.