Hybrid DNA Origami – Graphene Platform for Electrically‐Gated Nanoscale Motion

• DOI: 10.1002/admi.202400617
• Publication Date: 2024-11-07T07:56:44Z
• Authors: João D. G. Azevedo; Tiago Queirós; Filipe Camarneiro; Maria João Lopes; João Freitas; Agnes Purwidyantri; Praneetha Sundar ...; Soumya Chandrasekhar; Thorsten‐Lars Sch...; Pedro Alpuim; Jana B. Nieder
• Keywords: DNA origami

Abstract A proof‐of‐principle device for axial high‐resolution operation that combines a deoxyribonucleic acid (DNA) origami with functionalized graphene layer is presented, analyzed by nanoscopy. Along the DNA structure, ATTO‐488 fluorophores are bound at specific distances from graphene, where fluorescence lifetime values expected due to nearfield energy transfer processes. These characterized Fluorescence Lifetime Imaging Microscopy (FLIM). Through modulation of electrostatic potential under electrical gating, changes in lifetimes observed. understood as result changed coupling conditions between fluorophore and graphene's electronic states, combined vertical displacement structure matches molecular dimensions. hybrid architecture provided whose nanoscale depends on applied voltage regime. application these findings may be envisioned biocompatible sensing approaches, medical or environmental sensing.