Palladium(II)/Polyoxometalate‐Catalyzed Direct C‐3 Alkenylation of Indoles using Dioxygen as the Terminal Oxidant

• DOI: 10.1002/adsc.201201114
• Publication Date: 2013-05-15T21:13:29Z
• Authors: Qiufeng Huang; Qianqian Song; Jin Cai; Xiaofeng Zhang; Shen Lin
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractAn efficient and practical synthetic method has been developed for the preparation of 3‐vinylindoles by the direct CH olefination of indoles with alkenes. The transformation is catalyzed by palladium acetate combined with 12‐molybdophosphoric acid and uses oxygen as the terminal oxidant. 4‐Dimethylaminopyridine (DMAP) was observed to be an effective additive for the olefination reaction. Functional groups such as methoxy, benzyloxy, fluoro, bromo, ester, phenyl, and methyl were tolerated under the reaction conditions.