Inverse‐Electron‐Demand [4+2]‐Cycloaddition of 1,3,5‐triazinanes: Facile Approaches to Tetrahydroquinazolines

• DOI: 10.1002/adsc.201801063
• Publication Date: 2018-09-12T05:45:07Z
• Authors: Yongsheng Zheng; Liang Tu; Na Li; Rong Huang; Tao Feng; Huan Sun; Zhenghui Li; Jikai Liu
• Keywords: On demand

Abstract An unprecedented inverse‐electron‐demand [4+2] cycloaddition reaction of in situ generated aza‐ o ‐quinone methides with 1,3,5‐triazinanes has been developed under mild conditions, providing an efficient and approach to synthesize tetrahydroquinazolines high yields (up 99%) excellent functional group tolerance. This protocol represents the first example 1,3,5‐triazinanes. magnified image