Visible Light‐Mediated Functionalization of Selenocystine‐Containing Peptides

• DOI: 10.1002/adsc.202100373
• Publication Date: 2021-05-05T02:17:04Z
• Authors: Sindija Lapcinska; Pavels Dimitrijevs; Linards Lapcinskis; Pavel Arsenyan
• Keywords: Surface Modification; Visible spectrum

Abstract A straightforward and atom‐economic method for the functionalization of short selenocystine‐containing peptides is presented. This shown to be tolerant unprotected peptides. The detailed protocol based on generation a selenium radical via visible light‐initiated reaction in presence transition metal‐free photocatalyst. further oxidized an electrophile trapped by N ‐heterocycles. mechanism confirmed NMR, HRMS, UV, EPR cyclic voltammetry (CV) experiments photocatalyst emission quenching studies. employed synthesis selenocysteine‐containing indole‐based macrocycles intramolecular Se−C bond formation. magnified image