Recent Advances in the Transdermal Delivery of Protein Therapeutics with a Combinatorial System of Chemical Adjuvants and Physical Penetration Enhancements

• DOI: 10.1002/adtp.201900116
• Publication Date: 2020-01-16T18:34:47Z
• Authors: Young‐Hyeon An; Mihn Jeong Park; Joon Lee; Junghyeon Ko; Su‐Hwan Kim; Dong Hyeon Kang; Nathaniel S. Hwang
• Keywords: Nanocarriers; Iontophoresis; Penetration (warfare); Delivery system

Abstract Since the development of protein‐based therapeutics, research has been underway to deliver protein therapeutics into systemic circulation and target sites have actively conducted. Most require parenteral administration, due their intrinsic vulnerability susceptibility enzyme‐mediated degradation. Among routes transdermal delivery system regarded as a promising technique offering advantages painless ease termination, avoidance first‐pass metabolism. However, unlike small molecular drugs, limited skin penetration, macromolecular hydrophilic properties. Both cheimcal adjuvants (CAs)‐treatment methods physical penetration enhancer (PPEs) utilized increase permeability for therapeutics. The CAs, which include chemical enhancers nanocarriers, permit transport easily skin, by modifying stratum corneum (SC) or fabricating stable formulation. PPEs, including iontophoresis, electroporation, ultrasound, can improve therapeutic agent through disrupting SC. In this review, techniques both enhancement are introduced an overview latest approaches is provided.