A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions

• DOI: 10.1002/advs.201800935
• Publication Date: 2019-01-28T23:02:08Z
• Authors: Xenofon Strakosas; John Selberg; Xiaolin Zhang; Noah Christie; Peng‐Hao Hsu; Adah Almutairi; Marco Rolandi
• Keywords: Bioelectronics; Alkalosis; Degradation

Abstract Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling is the high buffering capacity of many media. To overcome this challenge, need to be able store deliver a large number protons on demand. Here, bioelectronic modulator controls using palladium nanoparticles contacts with surface area as proton storage medium developed. Reversible electronically triggered acidosis (low pH) alkalosis (high physiologically relevant buffer conditions are achieved. As proof principle, new platform used control degradation fluorescence acid sensitive polymeric microparticles loaded fluorescent dye.