Core–Shell‐Heterostructured Magnetic–Plasmonic Nanoassemblies with Highly Retained Magnetic–Plasmonic Activities for Ultrasensitive Bioanalysis in Complex Matrix

• DOI: 10.1002/advs.201902433
• Publication Date: 2019-12-13T08:18:07Z
• Authors: Liangwen Hao; Yuankui Leng; Lifeng Zeng; Xirui Chen; Jing Chen; Hong Duan; Xiaolin Huang; Yonghua Xiong; Xiaoyuan Chen
• Keywords: Bioanalysis

Herein, a facile self-assembly strategy for coassembling oleic acid-coated iron oxide nanoparticles (OC-IONPs) with oleylamine-coated gold (OA-AuNPs) to form colloidal magnetic-plasmonic nanoassemblies (MPNAs) is reported. The resultant MPNAs exhibit typical core-shell heterostructure comprising aggregated OA-AuNPs as plasmonic core surrounded by an assembled magnetic shell of OC-IONPs. Owing the high loading and reasonable spatial distribution OC-IONPs, highly retained activities simultaneously. Using intrinsic dual functionality separator signal transducer, it demonstrated that can achieve simultaneous manipulation optical detection on lateral flow immunoassay platform after surface functionalization recognition molecules. In conclusion, core-shell-heterostructured serve nanoanalytical separation concentration target compounds from complex biological samples using properties sensing properties.